Binding of transition metals to S100 proteins.

Gilston BA, Skaar EP, Chazin WJ
Sci China Life Sci. 2016 59 (8): 792-801

PMID: 27430886 · PMCID: PMC5123432 · DOI:10.1007/s11427-016-5088-4

The S100 proteins are a unique class of EF-hand Ca(2+) binding proteins distributed in a cell-specific, tissue-specific, and cell cycle-specific manner in humans and other vertebrates. These proteins are distinguished by their distinctive homodimeric structure, both intracellular and extracellular functions, and the ability to bind transition metals at the dimer interface. Here we summarize current knowledge of S100 protein binding of Zn(2+), Cu(2+) and Mn(2+) ions, focusing on binding affinities, conformational changes that arise from metal binding, and the roles of transition metal binding in S100 protein function.

MeSH Terms (12)

Amino Acid Sequence Animals Copper Humans Manganese Models, Molecular Protein Binding Protein Domains S100 Proteins Sequence Homology, Amino Acid Transition Elements Zinc

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