Sulphilimine cross-links in Goodpasture's disease.

Vanacore R, Pedchenko V, Bhave G, Hudson BG
Clin Exp Immunol. 2011 164 Suppl 1: 4-6

PMID: 21447121 · PMCID: PMC3095855 · DOI:10.1111/j.1365-2249.2011.04356.x

The sulphilimine cross-link of the Goodpasture (GP) autoantigen is a novel molecular mechanism (structural constraint) for conferring immune privilege to a site which otherwise is susceptible to structural changes that induce an immunogenic and pathogenic conformation. Perturbation of the assembly or cleavage of the sulphilimine cross-links could be a key factor in the aetiology of Goodpasture's disease in susceptible individuals.

© 2011 The Authors; Clinical and Experimental Immunology © 2011 British Society for Immunology.

MeSH Terms (8)

Anti-Glomerular Basement Membrane Disease Autoantigens Collagen Type IV Cross-Linking Reagents Epitopes, B-Lymphocyte Epitopes, T-Lymphocyte Humans Protein Conformation

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