Allosteric activators of glucokinase: potential role in diabetes therapy.

Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin KR, Hilliard DW, Kester RF, Mahaney PE, Marcus L, Qi L, Spence CL, Tengi J, Magnuson MA, Chu CA, Dvorozniak MT, Matschinsky FM, Grippo JF
Science. 2003 301 (5631): 370-3

PMID: 12869762 · DOI:10.1126/science.1084073

MeSH Terms (33)

Adaptor Proteins, Signal Transducing Allosteric Regulation Animals Blood Glucose Carrier Proteins Diabetes Mellitus, Type 2 Dose-Response Relationship, Drug Drug Evaluation, Preclinical Enzyme Activation Enzyme Activators Glucokinase Glucose Glucose Tolerance Test Homeostasis Humans Hypoglycemic Agents Insulin Insulin Secretion Intracellular Signaling Peptides and Proteins Islets of Langerhans Keto Acids Liver Liver Glycogen Male Mice Mice, Inbred C57BL Mice, Obese Proteins Rats Rats, Wistar Recombinant Proteins Stereoisomerism Thiazoles

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