Isolevuglandins and cardiovascular disease.

Davies SS, May-Zhang LS
Prostaglandins Other Lipid Mediat. 2018 139: 29-35

PMID: 30296489 · PMCID: PMC6555638 · DOI:10.1016/j.prostaglandins.2018.10.002

Isolevuglandins are 4-ketoaldehydes formed by peroxidation of arachidonic acid. Isolevuglandins react rapidly with primary amines including the lysyl residues of proteins to form irreversible covalent modifications. This review highlights evidence for the potential role of isolevuglandin modification in the disease processes, especially atherosclerosis, and some of the tools including small molecule dicarbonyl scavengers utilized to assess their contributions to disease.

Copyright © 2018. Published by Elsevier Inc.

MeSH Terms (6)

Arachidonic Acid Atherosclerosis Cardiovascular Diseases Humans Lipid Peroxidation Lipids

Connections (3)

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