Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of β-catenin.

Freeman TJ, Smith JJ, Chen X, Washington MK, Roland JT, Means AL, Eschrich SA, Yeatman TJ, Deane NG, Beauchamp RD
Gastroenterology. 2012 142 (3): 562-571.e2

PMID: 22115830 · PMCID: PMC3343368 · DOI:10.1053/j.gastro.2011.11.026

MeSH Terms (25)

Adenocarcinoma Adenomatous Polyposis Coli Aged Animals beta Catenin Binding Sites Bone Morphogenetic Proteins Colorectal Neoplasms Down-Regulation Female Genes, APC HCT116 Cells HEK293 Cells Humans Laser Capture Microdissection Male Mice Mice, Knockout Mice, Transgenic Middle Aged Oligonucleotide Array Sequence Analysis RNA, Messenger RNA Polymerase II Smad4 Protein Wnt Signaling Pathway

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