Keratin 19 gene drives Cre recombinase expression throughout the early postimplantation mouse embryo.

Means AL, Chytil A, Moses HL, Coffey RJ, Wright CV, Taketo MM, Grady WM
Genesis. 2005 42 (1): 23-7

PMID: 15828001 · DOI:10.1002/gene.20119

The development of Cre-lox technology has created new opportunities for studying the tissue-specific functions of genes in vivo during development and disease. We analyzed the spatial and temporal activity of Cre recombinase whose coding sequence was inserted into the endogenous locus for keratin 19. Rather than providing epithelial-specific recombination during organogenesis, this K19cre allele allows unexpected recombination in early embryonic development, resulting in recombination of a loxP-flanked allele throughout all tissues of the mouse, but with sparing of the extraembryonic endoderm, including the anterior visceral endoderm.

2005 Wiley-Liss, Inc.

MeSH Terms (11)

Animals Animals, Genetically Modified beta-Galactosidase Embryonic Development Female Gene Expression Regulation, Developmental Integrases Keratins Male Mice Recombination, Genetic

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