Transforming growth factors and related peptides in gastrointestinal neoplasia.

Coffey RJ, McCutchen CM, Graves-Deal R, Polk WH
J Cell Biochem Suppl. 1992 16G: 111-8

PMID: 1335097 · DOI:10.1002/jcb.240501120

Transforming growth factor alpha and beta 1 (TGF alpha and TGF beta 1) are representative members of two distinct and expanding families of polypeptide growth factors. TGF alpha is an epithelial cell mitogen, whereas TGF beta 1 inhibits epithelial cell growth; the role of these factors in contributing to the transformed phenotype is uncertain. Steady state mRNA expression for these growth factors and their receptors in a panel of human colon cancers and adjacent normal mucosa is presented. Based in part on results from transgenic mice in which TGF alpha is selectively overproduced in the mammary gland, a possible role for TGF alpha as a tumor promoter in the process of transformation is discussed.

MeSH Terms (16)

Animals Cell Transformation, Neoplastic Colon Colonic Neoplasms Female Gastrointestinal Neoplasms Humans Male Mice Mice, Transgenic Multigene Family Proto-Oncogenes Receptors, Cell Surface Receptors, Transforming Growth Factor beta Transforming Growth Factor alpha Transforming Growth Factor beta

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