Heterozygous null bone morphogenetic protein receptor type 2 mutations promote SRC kinase-dependent caveolar trafficking defects and endothelial dysfunction in pulmonary arterial hypertension.

Prewitt AR, Ghose S, Frump AL, Datta A, Austin ED, Kenworthy AK, de Caestecker MP
J Biol Chem. 2015 290 (2): 960-71

PMID: 25411245 · PMCID: PMC4294523 · DOI:10.1074/jbc.M114.591057

MeSH Terms (16)

Animals Bone Morphogenetic Protein 2 Bone Morphogenetic Protein Receptors, Type II Caveolae Caveolin 1 Endocytosis Endothelial Cells Familial Primary Pulmonary Hypertension Frameshift Mutation Heterozygote Humans Lung Mice Protein Transport Pyrimidines src-Family Kinases

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