Large scale zebrafish-based in vivo small molecule screen.

Hao J, Williams CH, Webb ME, Hong CC
J Vis Exp. 2010 (46)

PMID: 21248690 · PMCID: PMC3159654 · DOI:10.3791/2243

Given their small embryo size, rapid development, transparency, fecundity, and numerous molecular, morphological and physiological similarities to mammals, zebrafish has emerged as a powerful in vivo platform for phenotype-based drug screens and chemical genetic analysis. Here, we demonstrate a simple, practical method for large-scale screening of small molecules using zebrafish embryos.

MeSH Terms (4)

Animals Drug Evaluation, Preclinical Embryo, Nonmammalian Zebrafish

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