Evaluation of diffusion kurtosis imaging in ex vivo hypomyelinated mouse brains.

Kelm ND, West KL, Carson RP, Gochberg DF, Ess KC, Does MD
Neuroimage. 2016 124 (Pt A): 612-626

PMID: 26400013 · PMCID: PMC4651761 · DOI:10.1016/j.neuroimage.2015.09.028

Diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI), and DKI-derived white matter tract integrity metrics (WMTI) were experimentally evaluated ex vivo through comparisons to histological measurements and established magnetic resonance imaging (MRI) measures of myelin in two knockout mouse models with varying degrees of hypomyelination. DKI metrics of mean and radial kurtosis were found to be better indicators of myelin content than conventional DTI metrics. The biophysical WMTI model based on the DKI framework reported on axon water fraction with good accuracy in cases with near normal axon density, but did not provide additional specificity to myelination. Overall, DKI provided additional information regarding white matter microstructure compared with DTI, making it an attractive method for future assessments of white matter development and pathology.

Copyright © 2015 Elsevier Inc. All rights reserved.

MeSH Terms (16)

Animals Axons Brain Carrier Proteins Diffusion Diffusion Tensor Imaging Disease Models, Animal Magnetic Resonance Imaging Mice Mice, Knockout Myelin Sheath Rapamycin-Insensitive Companion of mTOR Protein Tuberous Sclerosis Tuberous Sclerosis Complex 2 Protein Tumor Suppressor Proteins White Matter

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