Genome Editing and Induced Pluripotent Stem Cell Technologies for Personalized Study of Cardiovascular Diseases.

Chun YW, Durbin MD, Hong CC
Curr Cardiol Rep. 2018 20 (6): 38

PMID: 29666931 · PMCID: PMC6204334 · DOI:10.1007/s11886-018-0984-9

PURPOSE OF REVIEW - The goal of this review is to highlight the potential of induced pluripotent stem cell (iPSC)-based modeling as a tool for studying human cardiovascular diseases. We present some of the current cardiovascular disease models utilizing genome editing and patient-derived iPSCs.

RECENT FINDINGS - The incorporation of genome-editing and iPSC technologies provides an innovative research platform, providing novel insight into human cardiovascular disease at molecular, cellular, and functional level. In addition, genome editing in diseased iPSC lines holds potential for personalized regenerative therapies. The study of human cardiovascular disease has been revolutionized by cellular reprogramming and genome editing discoveries. These exceptional technologies provide an opportunity to generate human cell cardiovascular disease models and enable therapeutic strategy development in a dish. We anticipate these technologies to improve our understanding of cardiovascular disease pathophysiology leading to optimal treatment for heart diseases in the future.

MeSH Terms (7)

Cardiovascular Diseases Cell Differentiation Gene Editing Humans Induced Pluripotent Stem Cells Models, Biological Precision Medicine

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