Life after MOMP.

Gama V, Deshmukh M
Mol Cell. 2015 58 (2): 199-201

PMID: 25884366 · PMCID: PMC4879686 · DOI:10.1016/j.molcel.2015.03.035

In this and a recent issue of Molecular Cell, Liu et al. (2015) and Ichim et al. (2015) report that low levels of caspase activity triggered by limited mitochondrial outer membrane permeabilization (MOMP) promote genomic instability that drives tumorigenesis, providing a novel and unexpected link between these effectors of apoptosis and cancer initiation.

Copyright © 2015 Elsevier Inc. All rights reserved.

MeSH Terms (6)

Animals Apoptosis DNA Damage Genomic Instability Humans Mitochondrial Membranes

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