Head of the Class: OLIG2 and Glioblastoma Phenotype.

Leelatian N, Ihrie RA
Cancer Cell. 2016 29 (5): 613-615

PMID: 27165737 · DOI:10.1016/j.ccell.2016.04.007

Genomic mapping has driven the classification of glioblastoma into distinct molecular subclasses, but mechanisms that regulate tumor subclass phenotypes are only now emerging. In this issue of Cancer Cell, Lu et al. describe a phenotypic switch from PDGFRA-enriched "proneural" to EGFR-enriched "classical" features in glioblastoma upon ablation of Olig2.

Copyright © 2016 Elsevier Inc. All rights reserved.

MeSH Terms (5)

Brain Neoplasms Glioblastoma Humans Phenotype Transcription Factors

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