A Dorsal SHH-Dependent Domain in the V-SVZ Produces Large Numbers of Oligodendroglial Lineage Cells in the Postnatal Brain.

Tong CK, Fuentealba LC, Shah JK, Lindquist RA, Ihrie RA, Guinto CD, Rodas-Rodriguez JL, Alvarez-Buylla A
Stem Cell Reports. 2015 5 (4): 461-70

PMID: 26411905 · PMCID: PMC4624995 · DOI:10.1016/j.stemcr.2015.08.013

Neural stem cells in different locations of the postnatal mouse ventricular-subventricular zone (V-SVZ) generate different subtypes of olfactory bulb (OB) interneurons. High Sonic hedgehog (SHH) signaling in the ventral V-SVZ regulates the production of specific subtypes of neurons destined for the OB. Here we found a transient territory of high SHH signaling in the dorsal V-SVZ beneath the corpus callosum (CC). Using intersectional lineage tracing in neonates to label dorsal radial glial cells (RGCs) expressing the SHH target gene Gli1, we demonstrate that this region produces many CC cells in the oligodendroglial lineage and specific subtypes of neurons in the OB. The number of oligodendroglial cells generated correlated with the levels of SHH signaling. This work identifies a dorsal domain of SHH signaling, which is an important source of oligodendroglial cells for the postnatal mammalian forebrain.

Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

MeSH Terms (13)

Animals Brain Cell Lineage Corpus Callosum Gene Expression Hedgehog Proteins Kruppel-Like Transcription Factors Mice Neural Stem Cells Olfactory Bulb Oligodendroglia Signal Transduction Zinc Finger Protein GLI1

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