Controlling COR competence: BCL-6 regulates neurogenesis and tumor suppression.

Chiang C, Ihrie RA
Cancer Cell. 2014 26 (6): 773-774

PMID: 25490438 · DOI:10.1016/j.ccell.2014.11.020

In this issue of Cancer Cell, Tiberi and colleagues describe a tumor-suppressor role for BCL6. In the cerebellum, BCL6 is required for the transition from proliferative precursor cell to a more differentiated immature neuron through repressing the expression of Hedgehog effectors, thus controlling a pathway that is aberrantly activated in medulloblastoma.

Copyright © 2014 Elsevier Inc. All rights reserved.

MeSH Terms (10)

Animals DNA-Binding Proteins Humans Medulloblastoma Neurogenesis Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-6 Repressor Proteins Signal Transduction Sirtuin 1

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