Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice.

Matsui Y, Halter SA, Holt JT, Hogan BL, Coffey RJ
Cell. 1990 61 (6): 1147-55

PMID: 2161707

To study the role of transforming growth factor alpha (TGF alpha) in normal mammary development and mammary neoplasia in vivo, we have generated transgenic mice in which a human TGF alpha cDNA is expressed under the control of the MMTV enhancer/promoter. Overexpression of TGF alpha in the mammary epithelium, as confirmed by in situ hybridization and immunohistochemistry, is associated with hyperplasia of alveoli and terminal ducts in virgin female and pregnant transgenic mice. A range of morphologic abnormalities including lobular hyperplasia, cystic hyperplasia, adenoma, and adenocarcinoma is seen in mammary tissue of transgenic females. In contrast, no morphologic abnormalities are seen in transgenic males in spite of TGF alpha overexpression in salivary glands and reproductive organs. TGF alpha can therefore act as an oncogene in vivo and appears to predispose mammary epithelium to neoplasia and carcinoma.

MeSH Terms (15)

Animals ErbB Receptors Female Hyperplasia Male Mammary Glands, Animal Mammary Neoplasms, Experimental Mammary Tumor Virus, Mouse Mice Mice, Transgenic Nucleic Acid Hybridization Reference Values RNA, Messenger Sex Factors Transforming Growth Factors

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