Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis.

Katholnig K, Schütz B, Fritsch SD, Schörghofer D, Linke M, Sukhbaatar N, Matschinger JM, Unterleuthner D, Hirtl M, Lang M, Herac M, Spittler A, Bergthaler A, Schabbauer G, Bergmann M, Dolznig H, Hengstschläger M, Magnuson MA, Mikula M, Weichhart T
JCI Insight. 2019 4 (20)

PMID: 31619583 · PMCID: PMC6824305 · DOI:10.1172/jci.insight.124164

MeSH Terms (24)

Animals Carcinogenesis Cell Line, Tumor Cell Proliferation Cells, Cultured Colitis, Ulcerative Colon Colorectal Neoplasms Dextran Sulfate Disease Models, Animal Female Humans Intestinal Mucosa Kaplan-Meier Estimate Macrophages Male Mechanistic Target of Rapamycin Complex 2 Mice Mice, Transgenic Morpholines Osteopontin Primary Cell Culture Prognosis Survival Rate

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