SLC30A10 is a cell surface-localized manganese efflux transporter, and parkinsonism-causing mutations block its intracellular trafficking and efflux activity.

Leyva-Illades D, Chen P, Zogzas CE, Hutchens S, Mercado JM, Swaim CD, Morrisett RA, Bowman AB, Aschner M, Mukhopadhyay S
J Neurosci. 2014 34 (42): 14079-95

PMID: 25319704 · PMCID: PMC4198546 · DOI:10.1523/JNEUROSCI.2329-14.2014

MeSH Terms (16)

Animals Caenorhabditis elegans Cation Transport Proteins Cell Membrane Cells, Cultured Female HeLa Cells Humans Intracellular Fluid Male Manganese Mice, Inbred C57BL Mutation Parkinsonian Disorders Protein Transport Zinc Transporter 8

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