Macrophages are essential for CTGF-mediated adult β-cell proliferation after injury.

Riley KG, Pasek RC, Maulis MF, Dunn JC, Bolus WR, Kendall PL, Hasty AH, Gannon M
Mol Metab. 2015 4 (8): 584-91

PMID: 26266091 · PMCID: PMC4529497 · DOI:10.1016/j.molmet.2015.05.002

Promotion of endogenous β-cell mass expansion could facilitate regeneration in patients with diabetes. We discovered that the secreted protein CTGF (aka CCN2) promotes adult β-cell replication and mass regeneration after injury via increasing β-cell immaturity and shortening the replicative refractory period. However, the mechanism of CTGF-mediated β-cell proliferation is unknown. Here we focused on whether CTGF alters cells of the immune system to enhance β-cell replication.

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