exhibits heterogeneous siderophore production within the vertebrate host.

Perry WJ, Spraggins JM, Sheldon JR, Grunenwald CM, Heinrichs DE, Cassat JE, Skaar EP, Caprioli RM
Proc Natl Acad Sci U S A. 2019 116 (44): 21980-21982

PMID: 31611408 · PMCID: PMC6825271 · DOI:10.1073/pnas.1913991116

Siderophores, iron-scavenging small molecules, are fundamental to bacterial nutrient metal acquisition and enable pathogens to overcome challenges imposed by nutritional immunity. Multimodal imaging mass spectrometry allows visualization of host-pathogen iron competition, by mapping siderophores within infected tissue. We have observed heterogeneous distributions of siderophores across infectious foci, challenging the paradigm that the vertebrate host is a uniformly iron-depleted environment to invading microbes.

Copyright © 2019 the Author(s). Published by PNAS.

MeSH Terms (11)

Abscess Animals Citrates Host-Pathogen Interactions Iron Mice Ornithine Siderophores Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Staphylococcal Infections Staphylococcus aureus

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