Advanced mass spectrometry technologies for the study of microbial pathogenesis.

Moore JL, Caprioli RM, Skaar EP
Curr Opin Microbiol. 2014 19: 45-51

PMID: 24997399 · PMCID: PMC4125470 · DOI:10.1016/j.mib.2014.05.023

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) has been successfully applied to the field of microbial pathogenesis with promising results, principally in diagnostic microbiology to rapidly identify bacteria based on the molecular profiles of small cell populations. Direct profiling of molecules from serum and tissue samples by MALDI MS provides a means to study the pathogen-host interaction and to discover potential markers of infection. Systematic molecular profiling across tissue sections represents a new imaging modality, enabling regiospecific molecular measurements to be made in situ, in both two-dimensional and three-dimensional analyses. Herein, we briefly summarize work that employs MALDI MS to study the pathogenesis of microbial infection.

Copyright © 2014 Elsevier Ltd. All rights reserved.

MeSH Terms (6)

Animals Host-Pathogen Interactions Humans Mass Spectrometry Microbiological Techniques Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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