MALDI imaging mass spectrometry: spatial molecular analysis to enable a new age of discovery.

Gessel MM, Norris JL, Caprioli RM
J Proteomics. 2014 107: 71-82

PMID: 24686089 · PMCID: PMC4104210 · DOI:10.1016/j.jprot.2014.03.021

Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) combines the sensitivity and selectivity of mass spectrometry with spatial analysis to provide a new dimension for histological analyses to provide unbiased visualization of the arrangement of biomolecules in tissue. As such, MALDI IMS has the capability to become a powerful new molecular technology for the biological and clinical sciences. In this review, we briefly describe several applications of MALDI IMS covering a range of molecular weights, from drugs to proteins. Current limitations and challenges are discussed along with recent developments to address these issues. This article is part of a Special Issue entitled: 20years of Proteomics in memory of Viatliano Pallini. Guest Editors: Luca Bini, Juan J. Calvete, Natacha Turck, Denis Hochstrasser and Jean-Charles Sanchez.

Copyright © 2014 Elsevier B.V. All rights reserved.

MeSH Terms (6)

Drug Discovery History, 20th Century History, 21st Century Humans Proteins Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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