3D imaging by mass spectrometry: a new frontier.

Seeley EH, Caprioli RM
Anal Chem. 2012 84 (5): 2105-10

PMID: 22276611 · PMCID: PMC3296907 · DOI:10.1021/ac2032707

Imaging mass spectrometry can generate three-dimensional volumes showing molecular distributions in an entire organ or animal through registration and stacking of serial tissue sections. Here, we review the current state of 3D imaging mass spectrometry as well as provide insights and perspectives on the process of generating 3D mass spectral data along with a discussion of the process necessary to generate a 3D image volume.

MeSH Terms (9)

Animals Brain Humans Imaging, Three-Dimensional Magnetic Resonance Imaging Peptides Proteins Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Spectrometry, Mass, Secondary Ion

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