Matrix pre-coated MALDI MS targets for small molecule imaging in tissues.

Grove KJ, Frappier SL, Caprioli RM
J Am Soc Mass Spectrom. 2011 22 (1): 192-5

PMID: 21472558 · PMCID: PMC4151471 · DOI:10.1007/s13361-010-0013-8

A new sample preparation method for MALDI tissue imaging has been developed for the analysis of low molecular weight compounds that employs matrix pre-coated MALDI targets. Tissue sections need only to be transferred onto the pre-coated target before analysis for fast and easy sample preparation. Pre-coated targets have a homogenous matrix coating with uniform crystals of approximately 1-2 μm and do not require solvents that may lead to analyte delocalization within a tissue section. We report here the use of matrix pre-coated targets for imaging of lipids, peptides, and pharmaceuticals in tissues.

© American Society for Mass Spectrometry, 2011

MeSH Terms (12)

Animals Female Gentisates Histocytochemistry Lipids Mice Mice, Inbred C57BL Microscopy, Electron, Scanning Molecular Imaging Peptides Pharmaceutical Preparations Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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