PI3-kinase and TGF-β in glomerular nephropathy: which comes first?

Pozzi A
Kidney Int. 2012 82 (5): 507-9

PMID: 22892855 · PMCID: PMC3725284 · DOI:10.1038/ki.2012.154

Transforming growth factor-β (TGF-β) and phosphatidylinositol-3-kinase (PI3 K) isoforms contribute to glomerular disease. Finer and colleagues define a temporal and selective role for the p110γ catalytic isoform of PI3 K, normally expressed by hematopoietic cells, and TGF-β in adriamycin-mediated glomerular injury. Early ectopic upregulation of p110γ by podocytes drives initial injury and proteinuria, whereas late upregulation of TGF-β drives fibrogenesis. Thus, proteinuria and renal fibrogenesis involve distinct signaling activated by p110γ and TGF-β, respectively.

MeSH Terms (9)

Animals Class I Phosphatidylinositol 3-Kinases Doxorubicin Glomerulosclerosis, Focal Segmental Kidney Male Proteinuria Signal Transduction Smad3 Protein

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