Regulation of matrix synthesis, remodeling and accumulation in glomerulosclerosis.

Pozzi A, Voziyan PA, Hudson BG, Zent R
Curr Pharm Des. 2009 15 (12): 1318-33

PMID: 19355971 · DOI:10.2174/138161209787846748

After injury the body normally undergoes a repair process, however when this event becomes deregulated the pathological condition of fibrosis occurs. There are many similarities with respect to the fundamental mechanisms that regulate sclerosis in different organ systems. In this review we utilize the pathological entity of glomerulosclerosis in the kidney to highlight some of the general paradigms whereby extracellular matrix (ECM) is deposited in greater quantities than it is degraded. Our review discusses how genetic and structural abnormalities of specific ECM components can result in fibrosis. In addition, we outline how some key growth factors, integrins and oxidative stress play a role in the development of glomerulosclerosis.

MeSH Terms (12)

Animals Extracellular Matrix Glomerulosclerosis, Focal Segmental Glycation End Products, Advanced Homeostasis Humans Integrins Intercellular Signaling Peptides and Proteins Kidney Glomerulus Oxidative Stress Protein Carbonylation Transcription Factors

Connections (6)

This publication is referenced by other Labnodes entities: