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NF-kappaB activation in melanoma.

Ueda Y, Richmond A
Pigment Cell Res. 2006 19 (2): 112-24

PMID: 16524427 · PMCID: PMC2668252 · DOI:10.1111/j.1600-0749.2006.00304.x

Metastatic melanoma is an aggressive skin cancer that is notoriously resistant to current cancer therapies. In human melanoma, nuclear factor-kappa B (NF-kappaB) is upregulated, leading to the deregulation of gene transcription. In this review, we discuss (i) the relationship between gene alteration in melanoma and upregulation of NF-kappaB, (ii) mechanisms by which activated NF-kappaB switch from pro-apoptotic to anti-apoptotic functions in melanoma and (iii) autocrine mechanisms that promote constitutive activation of NF-kappaB in metastatic melanoma.

MeSH Terms (10)

Animals Autocrine Communication Gene Expression Regulation, Neoplastic Humans Melanoma Neoplasm Metastasis NF-kappa B Skin Neoplasms Transcription, Genetic Up-Regulation

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