p63 and epithelial biology.

Barbieri CE, Pietenpol JA
Exp Cell Res. 2006 312 (6): 695-706

PMID: 16406339 · DOI:10.1016/j.yexcr.2005.11.028

The transcription factor p63 is a homologue of the tumor suppressor p53. Unlike p53, which is dispensable for normal development, p63 is critical for the development of stratified epithelial tissues such as epidermis, breast, and prostate. p63 encodes multiple protein isoforms with both transactivating and transcriptional repressor activities that can regulate a wide spectrum of target genes. p63 is also implicated in tumor formation and progression in stratified epithelia, with evidence for both tumor suppressive and oncogenic properties. This review will examine current data and hypotheses regarding the role of p63 in the development, maintenance, and tumorigenesis of stratified epithelium.

MeSH Terms (13)

Animals DNA DNA-Binding Proteins Epithelial Cells Epithelium Gene Expression Regulation Genes, Tumor Suppressor Humans Mice Phosphoproteins Trans-Activators Transcription Factors Tumor Suppressor Proteins

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