Expression of the protein related to Dan and Cerberus gene--prdc--During eye, pharyngeal arch, somite, and swim bladder development in zebrafish.

Müller II, Knapik EW, Hatzopoulos AK
Dev Dyn. 2006 235 (10): 2881-8

PMID: 16921498 · DOI:10.1002/dvdy.20925

The protein related to Dan and Cerberus, or PRDC, is a secreted glycoprotein, which belongs to the DAN subfamily of bone morphogenetic protein (BMP) antagonists. In zebrafish, prdc is expressed initially around 17 hours postfertilization in the developing eyes and the first two pharyngeal arches. Expression in the eye starts in the outer layers of the optic cup. Later, prdc expression domains are juxtaposed at the edges of the optic cup surrounding the choroid fissure, then gradually becoming restricted to a small site in the ventral marginal zone. Prdc expression in the arch mesenchyme expands stepwise to the remaining posterior arches. Prdc is also detectable in the ventral part of the somites and the mesenchyme of the swim bladder. The relatively late appearance during development is a unique feature of Prdc among BMP antagonists. Moreover, the complexity of the prdc expression pattern suggests possible roles in eye development, pharyngeal arch remodeling, somitogenesis, and swim bladder organogenesis.

(c) 2006 Wiley-Liss, Inc.

MeSH Terms (15)

Air Sacs Amino Acid Sequence Animals Branchial Region Eye Gene Expression Regulation, Developmental In Situ Hybridization Intercellular Signaling Peptides and Proteins Molecular Sequence Data Phylogeny Reverse Transcriptase Polymerase Chain Reaction Sequence Homology, Amino Acid Somites Zebrafish Zebrafish Proteins

Connections (3)

This publication is referenced by other Labnodes entities: