Intracellular granules of the renal medulla in a case of potassium depletion due to renal potassium wasting. Electron microscopic comparison with renal medullary granules in the potassium-depleted rat.

France R, Gray ME, Stone WJ, Swift LL
Am J Pathol. 1978 91 (2): 299-312

PMID: 565595 · PMCID: PMC2018195

An electron microscopic comparison was made of intracellular granules of the renal papilla and inner medulla in two types of potassium depletion: one in a 47-year-old white male with chronic potassium-wasting renal disease and the other in the experimentally depleted rat. The granules in both cases were composed of small and large vesicles; myelin figures; small particles; and dense bodies, with a partial, or complete, single limiting membrane. Ultrastructurally, the constituent elements of the granules were essentially the same in the two types of potassium depletion. It was concluded that the intracellular granules in the human tissue were the result of potassium depletion and a counterpart to those in the potassium-depleted rat.

MeSH Terms (15)

Animals Cytoplasmic Granules Female Glycoproteins Humans Hypokalemia Kidney Kidney Cortex Kidney Diseases Kidney Medulla Male Middle Aged Periodic Acid-Schiff Reaction Potassium Deficiency Rats

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