Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/╬▓Klotho Complex.

Kolumam G, Chen MZ, Tong R, Zavala-Solorio J, Kates L, van Bruggen N, Ross J, Wyatt SK, Gandham VD, Carano RA, Dunshee DR, Wu AL, Haley B, Anderson K, Warming S, Rairdan XY, Lewin-Koh N, Zhang Y, Gutierrez J, Baruch A, Gelzleichter TR, Stevens D, Rajan S, Bainbridge TW, Vernes JM, Meng YG, Ziai J, Soriano RH, Brauer MJ, Chen Y, Stawicki S, Kim HS, Comps-Agrar L, Luis E, Spiess C, Wu Y, Ernst JA, McGuinness OP, Peterson AS, Sonoda J
EBioMedicine. 2015 2 (7): 730-43

PMID: 26288846 · PMCID: PMC4534681 · DOI:10.1016/j.ebiom.2015.05.028

MeSH Terms (21)

Adiponectin Adipose Tissue, Brown Animals Antibodies, Bispecific Cell Line Energy Metabolism Fibroblast Growth Factors HEK293 Cells Humans Insulin Klotho Proteins Macaca fascicularis Male Membrane Proteins Mice, Inbred BALB C Mice, Inbred C57BL Mice, Obese Protein Binding Receptor, Fibroblast Growth Factor, Type 1 Thermogenesis Weight Loss

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