Circadian disruption leads to insulin resistance and obesity.

Shi SQ, Ansari TS, McGuinness OP, Wasserman DH, Johnson CH
Curr Biol. 2013 23 (5): 372-81

PMID: 23434278 · PMCID: PMC3595381 · DOI:10.1016/j.cub.2013.01.048

Disruption of circadian (daily) timekeeping enhances the risk of metabolic syndrome, obesity, and type 2 diabetes. While clinical observations have suggested that insulin action is not constant throughout the 24 hr cycle, its magnitude and periodicity have not been assessed. Moreover, when circadian rhythmicity is absent or severely disrupted, it is not known whether insulin action will lock to the peak, nadir, or mean of the normal periodicity of insulin action.

MeSH Terms (11)

Animals ARNTL Transcription Factors Circadian Rhythm Diet, High-Fat Glucose Clamp Technique Insulin Insulin Resistance Male Mice Mice, Knockout Obesity

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