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Matrix metalloproteinase 9 opposes diet-induced muscle insulin resistance in mice.

Kang L, Mayes WH, James FD, Bracy DP, Wasserman DH
Diabetologia. 2014 57 (3): 603-13

PMID: 24305966 · PMCID: PMC4155606 · DOI:10.1007/s00125-013-3128-1

Increased extracellular matrix (ECM) collagen is a characteristic of muscle insulin resistance. Matrix metalloproteinase (MMP) 9 is a primary enzyme that degrades collagen IV (ColIV). As a component of the basement membrane, ColIV plays a key role in ECM remodelling. We tested the hypotheses that genetic deletion of MMP9 in mice increases muscle ColIV, induces insulin resistance in lean mice and worsens diet-induced muscle insulin resistance.

MeSH Terms (15)

Animals Blood Glucose Body Weight Collagen Type V Diet, High-Fat Extracellular Matrix Gene Deletion Glucose Clamp Technique Immunohistochemistry Insulin Insulin Resistance Matrix Metalloproteinase 9 Mice Muscle, Skeletal Vascular Endothelial Growth Factor A

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