AMP-activated protein kinase (AMPK)α2 plays a role in determining the cellular fate of glucose in insulin-resistant mouse skeletal muscle.

Lee-Young RS, Bonner JS, Mayes WH, Iwueke I, Barrick BA, Hasenour CM, Kang L, Wasserman DH
Diabetologia. 2013 56 (3): 608-17

PMID: 23224579 · PMCID: PMC4075509 · DOI:10.1007/s00125-012-2787-7

We determined whether: (1) an acute lipid infusion impairs skeletal muscle AMP-activated protein kinase (AMPK)α2 activity, increases inducible nitric oxide synthase (iNOS) and causes peripheral insulin resistance in conscious, unstressed, lean mice; and (2) restoration of AMPKα2 activity during the lipid infusion attenuates the increase in iNOS and reverses the defect in insulin sensitivity in vivo.

MeSH Terms (10)

AMP-Activated Protein Kinases Animals Glucose Glycogen Insulin Resistance Male Mice Mice, Inbred C57BL Muscle, Skeletal Nitric Oxide Synthase Type II

Connections (3)

This publication is referenced by other Labnodes entities: