Hepatic glucagon action is essential for exercise-induced reversal of mouse fatty liver.

Berglund ED, Lustig DG, Baheza RA, Hasenour CM, Lee-Young RS, Donahue EP, Lynes SE, Swift LL, Charron MJ, Damon BM, Wasserman DH
Diabetes. 2011 60 (11): 2720-9

PMID: 21885872 · PMCID: PMC3198076 · DOI:10.2337/db11-0455

Exercise is an effective intervention to treat fatty liver. However, the mechanism(s) that underlie exercise-induced reductions in fatty liver are unclear. Here we tested the hypothesis that exercise requires hepatic glucagon action to reduce fatty liver.

MeSH Terms (16)

Animals Body Weight Dietary Fats Disease Progression Fatty Liver Glucagon Lipid Metabolism Liver Magnetic Resonance Imaging Male Mice Mice, Inbred C57BL Mice, Knockout Motor Activity Receptors, Glucagon Signal Transduction

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