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Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice.

Kang L, Ayala JE, Lee-Young RS, Zhang Z, James FD, Neufer PD, Pozzi A, Zutter MM, Wasserman DH
Diabetes. 2011 60 (2): 416-26

PMID: 21270253 · PMCID: PMC3028340 · DOI:10.2337/db10-1116

The hypothesis that high-fat (HF) feeding causes skeletal muscle extracellular matrix (ECM) remodeling in C57BL/6J mice and that this remodeling contributes to diet-induced muscle insulin resistance (IR) through the collagen receptor integrin α(2)β(1) was tested.

MeSH Terms (22)

Analysis of Variance Animals Blotting, Western Collagen Type III Collagen Type V Diet Extracellular Matrix Glucose Clamp Technique Immunohistochemistry Insulin Insulin Resistance Integrin alpha2beta1 Matrix Metalloproteinase 9 Mice Mice, Knockout Muscle, Skeletal Phosphodiesterase 5 Inhibitors Piperazines Purines Reverse Transcriptase Polymerase Chain Reaction Sildenafil Citrate Sulfones

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