Ibuprofen use during extreme exercise: effects on oxidative stress and PGE2.

McAnulty SR, Owens JT, McAnulty LS, Nieman DC, Morrow JD, Dumke CL, Milne GL
Med Sci Sports Exerc. 2007 39 (7): 1075-9

PMID: 17596774 · DOI:10.1249/mss.0b13e31804a8611

PURPOSE - Oxidative stress was examined with use (N = 29) or nonuse (N = 25) of ibuprofen in ultramarathoners after the Western States Endurance Run.

METHODS - Oxidative stress was assessed by measuring plasma and urinary F2-isoprostanes, plasma nitrite, and plasma urate. A urinary prostaglandin E2 metabolite (PGE-M) was used as an end point to assess ibuprofen use. Ibuprofen users consumed 600 and 1200 mg of ibuprofen the day before and on race day, respectively, and nonusers avoided all antiinflammatory medications. Blood and urine were collected in the morning before the race and immediately after the race.

RESULTS - Use compared with nonuse of ibuprofen significantly increased plasma (P
CONCLUSION - Ibuprofen use compared with nonuse by athletes competing in a 160-km race was associated with significantly increased oxidative stress.

MeSH Terms (12)

Adult Anti-Inflammatory Agents, Non-Steroidal California Female Humans Ibuprofen Male Middle Aged Oxidative Stress Physical Exertion Prostaglandins E Running

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