Human MRP3 transporter: identification of the 5'-flanking region, genomic organization and alternative splice variants.

Fromm MF, Leake B, Roden DM, Wilkinson GR, Kim RB
Biochim Biophys Acta. 1999 1415 (2): 369-74

PMID: 9889399 · DOI:10.1016/s0005-2736(98)00233-8

In humans, at least six members of the multidrug resistance-associated protein (MRP) family are thought to exist. Here we report the molecular cloning of two splice variants of MRP3 from human liver. In addition, MRP3 genomic organization including the 5'-flanking region and a major portion of the MRP3 intron-exon organization are identified and characterized.

MeSH Terms (10)

Alternative Splicing Amino Acid Sequence ATP-Binding Cassette Transporters Base Sequence Binding Sites Drug Resistance, Multiple Humans Liver Molecular Sequence Data Multidrug Resistance-Associated Proteins

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