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t(17;19) in Children with Acute Lymphocytic Leukemia: A Report of 3 Cases and a Review of the Literature.

Minson KA, Prasad P, Vear S, Borinstein S, Ho R, Domm J, Frangoul H
Case Rep Hematol. 2013 2013: 563291

PMID: 23346431 · PMCID: PMC3549381 · DOI:10.1155/2013/563291

Several cytogenetic abnormalities identified in patients with childhood acute lymphocytic leukemia (ALL) have been associated with a poor prognosis. There are several case reports in the literature describing t(17;19) in children with ALL. This translocation has been associated with hypercalcemia, coagulopathy, and poor outcome. We present three cases of ALL with t(17;19) treated at our institution and review the outcome of children reported in the medical literature.

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