The Gaddy Lab is a microbiological laboratory that focuses on the interaction of bacterial pathogens with host cells.  We use molecular biology, bacterial genetics, biochemistry, and high resolution microscopy tools to study these interactions.  Our goal is to elucidate the molecular mechanisms behind bacterial pathogenesis in an effort to identify new potential antimicrobial therapeutic targets.  We focus our studies on the landscape of the bacterial cell surface and the contribution of metal homeostasis to the interaction of host and pathogen cells.  

Publications

Featured publications

  1. Role of connexin 43 in Helicobacter pylori VacA-induced cell death. Radin JN, González-Rivera C, Frick-Cheng AE, Sheng J, Gaddy JA, Rubin DH, Algood HM, McClain MS, Cover TL (2014) Infect Immun 82(1): 423-32
    › Primary publication · 24191302 (PubMed) · PMC3911829 (PubMed Central)
  2. Control of gene expression in Helicobacter pylori using the Tet repressor. McClain MS, Duncan SS, Gaddy JA, Cover TL (2013) J Microbiol Methods 95(3): 336-41
    › Primary publication · 24113399 (PubMed) · PMC3856897 (PubMed Central)
  3. Impaired autophagy, defective T cell homeostasis, and a wasting syndrome in mice with a T cell-specific deletion of Vps34. Parekh VV, Wu L, Boyd KL, Williams JA, Gaddy JA, Olivares-Villagómez D, Cover TL, Zong WX, Zhang J, Van Kaer L (2013) J Immunol 190(10): 5086-101
    › Primary publication · 23596309 (PubMed) · PMC3646937 (PubMed Central)
  4. Flagellar localization of a Helicobacter pylori autotransporter protein. Radin JN, Gaddy JA, González-Rivera C, Loh JT, Algood HM, Cover TL (2013) MBio 4(2): e00613-12
    › Primary publication · 23572556 (PubMed) · PMC3622936 (PubMed Central)
  5. High dietary salt intake exacerbates Helicobacter pylori-induced gastric carcinogenesis. Gaddy JA, Radin JN, Loh JT, Zhang F, Washington MK, Peek RM, Algood HM, Cover TL (2013) Infect Immun 81(6): 2258-67
    › Primary publication · 23569116 (PubMed) · PMC3676043 (PubMed Central)
  6. Functional plasticity in the type IV secretion system of Helicobacter pylori. Barrozo RM, Cooke CL, Hansen LM, Lam AM, Gaddy JA, Johnson EM, Cariaga TA, Suarez G, Peek RM, Cover TL, Solnick JV (2013) PLoS Pathog 9(2): e1003189
    › Primary publication · 23468628 (PubMed) · PMC3585145 (PubMed Central)
  7. Effect of ethanol on differential protein production and expression of potential virulence functions in the opportunistic pathogen Acinetobacter baumannii. Nwugo CC, Arivett BA, Zimbler DL, Gaddy JA, Richards AM, Actis LA (2012) PLoS One 7(12): e51936
    › Primary publication · 23284824 (PubMed) · PMC3527336 (PubMed Central)
  8. Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans. Noto JM, Gaddy JA, Lee JY, Piazuelo MB, Friedman DB, Colvin DC, Romero-Gallo J, Suarez G, Loh J, Slaughter JC, Tan S, Morgan DR, Wilson KT, Bravo LE, Correa P, Cover TL, Amieva MR, Peek RM (2013) J Clin Invest 123(1): 479-92
    › Primary publication · 23257361 (PubMed) · PMC3533289 (PubMed Central)
  9. Alterations in Helicobacter pylori triggered by contact with gastric epithelial cells. Johnson EM, Gaddy JA, Cover TL (2012) Front Cell Infect Microbiol : 17
    › Primary publication · 22919609 (PubMed) · PMC3417513 (PubMed Central)
  10. Role of acinetobactin-mediated iron acquisition functions in the interaction of Acinetobacter baumannii strain ATCC 19606T with human lung epithelial cells, Galleria mellonella caterpillars, and mice. Gaddy JA, Arivett BA, McConnell MJ, López-Rojas R, Pachón J, Actis LA (2012) Infect Immun 80(3): 1015-24
    › Primary publication · 22232188 (PubMed) · PMC3294665 (PubMed Central)

Community Leaders

Contact Information

1161 21st Ave. S. Medical Center North A2200
Nashville, TN 37232
United States
6157794452 (p)

Jennifer Gaddy
6157794452 (p)
Email

Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

Aging bacteria Bacterial Adhesion Connexin 43 Enzyme Stability Ethanol Gastric Mucosa Helicobacter Infections Hemin Indoleacetic Acids Locomotion metal homeostasis Mice, Inbred C57BL microscopy Natural Killer T-Cells Operator Regions, Genetic pathogen Proteome Pulmonary Alveoli Recombination, Genetic Siderophores Stomach Transcription, Genetic Virulence Factors