The mission of the Vanderbilt Transgenic Mouse/ES Cell Shared Resource (TMESCSR) is to provide services, consultation and collaboration to enable the generation, storage and regeneration of genetically altered mice at Vanderbilt.  

We have many years of experience in generating novel transgenic mouse models and are happy to discuss your project with you.  

The following procedures are provided on a fee-for-service basis:

We are sorry, but due to low utilization we can no longer provide mouse ES cell-based services on a routine, fee-for-service basis (please see notification letter).  However, we are happy to discuss how projects that require the genetic manipulation of mouse ES cells might still be achieved.  

In addition, we are pleased to discuss collaborative projects that require the development of new methods and techniques.  

Please email Ms. Jennifer Skelton or Dr. Mark Magnuson with a short description of what you would like to do.

 

Publications

Most recent publications

  1. p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion. Helman A, Klochendler A, Azazmeh N, Gabai Y, Horwitz E, Anzi S, Swisa A, Condiotti R, Granit RZ, Nevo Y, Fixler Y, Shreibman D, Zamir A, Tornovsky-Babeay S, Dai C, Glaser B, Powers AC, Shapiro AM, Magnuson MA, Dor Y, Ben-Porath I (2016) Nat Med 22(4): 412-20
    › Citation · 26950362 (PubMed)
  2. Diabetes Caused by Elastase-Cre-Mediated Pdx1 Inactivation in Mice. Kodama S, Nakano Y, Hirata K, Furuyama K, Horiguchi M, Kuhara T, Masui T, Kawaguchi M, Gannon M, Wright CV, Uemoto S, Kawaguchi Y (2016) Sci Rep : 21211
    › Citation · 26887806 (PubMed) · PMC4758062 (PubMed Central)
  3. Sustained expression of GLP-1 receptor differentially modulates β-cell functions in diabetic and nondiabetic mice. Kubo F, Miyatsuka T, Sasaki S, Takahara M, Yamamoto Y, Shimo N, Watada H, Kaneto H, Gannon M, Matsuoka TA, Shimomura I (2016) Biochem Biophys Res Commun 471(1): 68-74
    › Citation · 26854076 (PubMed)
  4. The PGE2 EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice. Ceddia RP, Lee D, Maulis MF, Carboneau BA, Threadgill DW, Poffenberger G, Milne G, Boyd KL, Powers AC, McGuinness OP, Gannon M, Breyer RM (2016) Endocrinology 157(1): 220-32
    › Citation · 26485614 (PubMed) · PMC4701878 (PubMed Central)
  5. Targeting Anti-Insulin B Cell Receptors Improves Receptor Editing in Type 1 Diabetes-Prone Mice. Bonami RH, Thomas JW (2015) J Immunol 195(10): 4730-41
    › Citation · 26432895 (PubMed) · PMC4637270 (PubMed Central)
  6. NF-κB-dependent airway inflammation triggers systemic insulin resistance. Cyphert TJ, Morris RT, House LM, Barnes TM, Otero YF, Barham WJ, Hunt RP, Zaynagetdinov R, Yull FE, Blackwell TS, McGuinness OP (2015) Am J Physiol Regul Integr Comp Physiol 309(9): R1144-52
    › Citation · 26377563 (PubMed) · PMC4666958 (PubMed Central)
  7. Wnt10b Gain-of-Function Improves Cardiac Repair by Arteriole Formation and Attenuation of Fibrosis. Paik DT, Rai M, Ryzhov S, Sanders LN, Aisagbonhi O, Funke MJ, Feoktistov I, Hatzopoulos AK (2015) Circ Res 117(9): 804-16
    › Citation · 26338900 (PubMed) · PMC4600464 (PubMed Central)
  8. Macrophages are essential for CTGF-mediated adult β-cell proliferation after injury. Riley KG, Pasek RC, Maulis MF, Dunn JC, Bolus WR, Kendall PL, Hasty AH, Gannon M (2015) Mol Metab 4(8): 584-91
    › Citation · 26266091 (PubMed) · PMC4529497 (PubMed Central)
  9. Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion. Golson ML, Dunn JC, Maulis MF, Dadi PK, Osipovich AB, Magnuson MA, Jacobson DA, Gannon M (2015) Diabetes 64(11): 3829-38
    › Citation · 26251404 (PubMed) · PMC4613976 (PubMed Central)
  10. The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma. Krah NM, De La O JP, Swift GH, Hoang CQ, Willet SG, Chen Pan F, Cash GM, Bronner MP, Wright CV, MacDonald RJ, Murtaugh LC (2015) Elife
    › Citation · 26151762 (PubMed) · PMC4536747 (PubMed Central)

The Transgenic Mouse/ES Cell Shared Resource is supported by NIH grants DK020593 and CA68485.  Please acknowledge this in your publications.

Community Leaders

Contact Information

9410 MRB IV
2213 Garland Avenue
Nashville, TN 37232
United States

No contact person provided

Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

Adrenergic Uptake Inhibitors CRISPR cryopreservation Diabetes Mellitus, Type 2 Electrophoresis, Polyacrylamide Gel Ephrin-B2 Fluorescent Antibody Technique Fluoxetine Gene Duplication Genes, Immunoglobulin Heavy Chain Immunoblotting Insulin Knockout Lipopolysaccharides Lung Neoplasms Membrane Potentials Mice, Knockout Moloney murine leukemia virus Mouse Receptors, N-Methyl-D-Aspartate rederivation Reflex, Startle Regeneration Reoviridae SOXB1 Transcription Factors Transgenic