The Transgenic Mouse / ES Cell Shared Resource assists investigators in generating, maintaining and storing germline-altered mice.  This resource, which has been in existence for over 22 years, has generated over 2600 transgenic founder mice from 700 different DNA constructs and 5000 chimeric mice from over 800 different mouse ES cell clones.  Prior to the discovery of the CRISPR/Cas system, the TMESCSR generated over 160 different gene-targeted mice. Since 2013, the TMESCSR has generated over 275 mutant pups by CRISPR/Cas injections from over 70 different projects.

The Vanderbilt Transgenic Mouse/ES Cell Shared Resource (TMESCSR) provides services, consultation and collaborations to enable the generation, storage and regeneration of genetically altered mice at Vanderbilt.  

We have many years of experience in generating novel transgenic mouse models and are happy to discuss your project with you.  

The following procedures are currently provided on a fee-for-service basis:

We are sorry, but due to low utilization we can no longer provide mouse ES cell-based services on a routine, fee-for-service basis (please see notification letter).    

In addition, we are pleased to discuss collaborative projects that involve the development of new strategies and techniques.

Please email Ms. Jennifer Skelton or Dr. Mark Magnuson with a short description of what you would like to do.


Featured Collections


Featured publications

  1. Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter. Kahle KT, Flores B, Bharucha-Goebel D, Zhang J, Donkervoort S, Hegde M, Hussain G, Duran D, Liang B, Sun D, Bönnemann CG, Delpire E (2016) Sci Signal 9(439): ra77
    › Citation · 27485015 (PubMed)

The Transgenic Mouse/ES Cell Shared Resource is supported by NIH grants DK020593 and CA68485.  Please acknowledge this in your publications.

Community Leaders

Contact Information

9410 MRB IV
2213 Garland Avenue
Nashville, TN 37232
United States

No contact person provided

Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

Adrenergic Uptake Inhibitors CRISPR cryopreservation Diabetes Mellitus, Type 2 Electrophoresis, Polyacrylamide Gel Ephrin-B2 Fluorescent Antibody Technique Fluoxetine Gene Duplication Genes, Immunoglobulin Heavy Chain Immunoblotting Insulin Knockout Lipopolysaccharides Lung Neoplasms Membrane Potentials Mice, Knockout Moloney murine leukemia virus Mouse Receptors, N-Methyl-D-Aspartate rederivation Reflex, Startle Regeneration Reoviridae SOXB1 Transcription Factors Transgenic