James (Tom) Thomas Laboratory

The Thomas laboratory investigates immune tolerance lesions in type 1 diabetes, in an effort to identify novel ways to correct them to provide therapeutic benefit to patients with autoimmune disease.

Publications

Featured publications

  1. B Cell Receptor Affinity for Insulin Dictates Autoantigen Acquisition and B Cell Functionality in Autoimmune Diabetes. Packard TA, Smith MJ, Conrad FJ, Johnson SA, Getahun A, Lindsay RS, Hinman RM, Friedman RS, Thomas JW, Cambier JC (2016) J Clin Med 5(11)
    › Primary publication · 27834793 (PubMed) · PMC5126795 (PubMed Central)
  2. Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system. Cho SH, Raybuck AL, Stengel K, Wei M, Beck TC, Volanakis E, Thomas JW, Hiebert S, Haase VH, Boothby MR (2016) Nature 537(7619): 234-238
    › Primary publication · 27501247 (PubMed) · PMC5161594 (PubMed Central)
  3. Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites. Wan X, Thomas JW, Unanue ER (2016) J Exp Med 213(6): 967-78
    › Primary publication · 27139492 (PubMed) · PMC4886365 (PubMed Central)
  4. Targeting Anti-Insulin B Cell Receptors Improves Receptor Editing in Type 1 Diabetes-Prone Mice. Bonami RH, Thomas JW (2015) J Immunol 195(10): 4730-41
    › Primary publication · 26432895 (PubMed) · PMC4637270 (PubMed Central)
  5. Reversing Tolerance in Isotype Switch-Competent Anti-Insulin B Lymphocytes. Williams JM, Bonami RH, Hulbert C, Thomas JW (2015) J Immunol 195(3): 853-64
    › Primary publication · 26109644 (PubMed) · PMC4506889 (PubMed Central)
  6. The development and utility of a novel scale that quantifies the glycemic progression toward type 1 diabetes over 6 months. Sosenko JM, Skyler JS, Beam CA, Boulware D, Mahon JL, Krischer JP, Greenbaum CJ, Rafkin LE, Matheson D, Herold KC, Palmer JP, Type 1 Diabetes TrialNet and Diabetes Prevention Trial–Type 1 Study Groups (2015) Diabetes Care 38(5): 940-2
    › Primary publication · 25758770 (PubMed) · PMC4407750 (PubMed Central)
  7. A new approach for diagnosing type 1 diabetes in autoantibody-positive individuals based on prediction and natural history. Sosenko JM, Skyler JS, DiMeglio LA, Beam CA, Krischer JP, Greenbaum CJ, Boulware D, Rafkin LE, Matheson D, Herold KC, Mahon J, Palmer JP, Type 1 Diabetes TrialNet Study Group, Diabetes Prevention Trial-Type 1 Study Group (2015) Diabetes Care 38(2): 271-6
    › Primary publication · 25519451 (PubMed) · PMC4302258 (PubMed Central)
  8. NFATc2 (NFAT1) assists BCR-mediated anergy in anti-insulin B cells. Bonami RH, Wolfle WT, Thomas JW, Kendall PL (2014) Mol Immunol 62(2): 321-8
    › Primary publication · 24507801 (PubMed) · PMC4125564 (PubMed Central)
  9. Requirement for Rictor in homeostasis and function of mature B lymphoid cells. Lee K, Heffington L, Jellusova J, Nam KT, Raybuck A, Cho SH, Thomas JW, Rickert RC, Boothby M (2013) Blood 122(14): 2369-79
    › Primary publication · 23958952 (PubMed) · PMC3790507 (PubMed Central)
  10. B cell-intrinsic and -extrinsic regulation of antibody responses by PARP14, an intracellular (ADP-ribosyl)transferase. Cho SH, Raybuck A, Wei M, Erickson J, Nam KT, Cox RG, Trochtenberg A, Thomas JW, Williams J, Boothby M (2013) J Immunol 191(6): 3169-78
    › Primary publication · 23956424 (PubMed) · PMC3770464 (PubMed Central)

Community Leaders

Contact Information

1161 21st Ave. South
T3207 MCN
Nashville, TN 37232
USA

Chrys Hulbert
615-343-1009 (p)
615-322-6248 (f)
Email

Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

Acute Disease antibody autoimmunity B cells B lymphocytes Cell Separation Chimera Chromosomes, Human, Pair 6 Complementarity Determining Regions diabetes Genes, Immunoglobulin Heavy Chain Glucose immune tolerance immunology insulin Interferon-gamma Interleukins Membrane Glycoproteins Mice, Inbred NOD Mice, Knockout Mutagenesis, Site-Directed Pancreatitis Polymerase Chain Reaction Recombinant Fusion Proteins ROC Curve S100 Calcium-Binding Protein A4 Structure-Activity Relationship Tumor Cells, Cultured type 1 diabetes