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The Center for Quantitative Systems Biology (QSB Center) is a campus-wide center led by Dr. Vito Quaranta. Its mission is to transform systems biology into a sustainable program of excellence at Vanderbilt University. Its specific goals are to support the Vanderbilt systems biology community by enhancing research, education and training in mixed approaches requiring mathematical modeling and experimentation.

Center Overarching Goals 

  1. Integrate laboratories from diverse disciplines on Campus
  2. Expand educational and training opportunities in Systems Biology offered to undergraduate and graduate students
  3. Provide an institution-wide platform for data acquisition, storage and analysis, focused towards local strengths such as single-cell biology
  4. Promote advanced computation on campus
  5. Serve as an incubator for systems-level science to expand the funded research portfolio at VU

Center Director: Vito Quaranta, M.D.

 For an interactive map of our affiliates, click the image.

QSBC Interactive Map

Past Meetings

10th Annual q-bio Conference

Date: July 27-30, 2016

Location: Vanderbilt University in Nashville, TN





Featured publications

  1. An unbiased metric of antiproliferative drug effect in vitro. Harris LA, Frick PL, Garbett SP, Hardeman KN, Paudel BB, Lopez CF, Quaranta V, Tyson DR (2016) Nat Methods 13(6): 497-500
    › Primary publication · 27135974 (PubMed) · PMC4887341 (PubMed Central)
  2. KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes. McKenzie AJ, Hoshino D, Hong NH, Cha DJ, Franklin JL, Coffey RJ, Patton JG, Weaver AM (2016) Cell Rep 15(5): 978-87
    › Primary publication · 27117408 (PubMed) · PMC4857875 (PubMed Central)
  3. High-Dimensional Analysis of Acute Myeloid Leukemia Reveals Phenotypic Changes in Persistent Cells during Induction Therapy. Ferrell PB, Diggins KE, Polikowsky HG, Mohan SR, Seegmiller AC, Irish JM (2016) PLoS One 11(4): e0153207
    › Primary publication · 27074138 (PubMed) · PMC4830605 (PubMed Central)
  4. CASP11--An Evaluation of a Modular BCL::Fold-Based Protein Structure Prediction Pipeline. Fischer AW, Heinze S, Putnam DK, Li B, Pino JC, Xia Y, Lopez CF, Meiler J (2016) PLoS One 11(4): e0152517
    › Primary publication · 27046050 (PubMed) · PMC4821492 (PubMed Central)
  5. Myelodysplastic Syndrome Revealed by Systems Immunology in a Melanoma Patient Undergoing Anti-PD-1 Therapy. Greenplate AR, Johnson DB, Roussel M, Savona MR, Sosman JA, Puzanov I, Ferrell PB, Irish JM (2016) Cancer Immunol Res 4(6): 474-80
    › Primary publication · 26966176 (PubMed) · PMC4891280 (PubMed Central)
  6. The use of fluorescently-tagged apoptolidins in cellular uptake and response studies. Chong KM, Leelatian N, Deguire SM, Brockman AA, Earl D, Ihrie RA, Irish JM, Bachmann BO, Sulikowski GA (2016) J Antibiot (Tokyo) 69(4): 327-30
    › Primary publication · 26956792 (PubMed)
  7. The phenotypic legacy of admixture between modern humans and Neandertals. Simonti CN, Vernot B, Bastarache L, Bottinger E, Carrell DS, Chisholm RL, Crosslin DR, Hebbring SJ, Jarvik GP, Kullo IJ, Li R, Pathak J, Ritchie MD, Roden DM, Verma SS, Tromp G, Prato JD, Bush WS, Akey JM, Denny JC, Capra JA (2016) Science 351(6274): 737-41
    › Primary publication · 26912863 (PubMed) · PMC4849557 (PubMed Central)
  8. Joint mouse-human phenome-wide association to test gene function and disease risk. Wang X, Pandey AK, Mulligan MK, Williams EG, Mozhui K, Li Z, Jovaisaite V, Quarles LD, Xiao Z, Huang J, Capra JA, Chen Z, Taylor WL, Bastarache L, Niu X, Pollard KS, Ciobanu DC, Reznik AO, Tishkov AV, Zhulin IB, Peng J, Nelson SF, Denny JC, Auwerx J, Lu L, Williams RW (2016) Nat Commun : 10464
    › Primary publication · 26833085 (PubMed) · PMC4740880 (PubMed Central)
  9. Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy. Johnson DB, Estrada MV, Salgado R, Sanchez V, Doxie DB, Opalenik SR, Vilgelm AE, Feld E, Johnson AS, Greenplate AR, Sanders ME, Lovly CM, Frederick DT, Kelley MC, Richmond A, Irish JM, Shyr Y, Sullivan RJ, Puzanov I, Sosman JA, Balko JM (2016) Nat Commun : 10582
    › Primary publication · 26822383 (PubMed) · PMC4740184 (PubMed Central)
  10. In Vivo Autofluorescence Imaging of Tumor Heterogeneity in Response to Treatment. Shah AT, Diggins KE, Walsh AJ, Irish JM, Skala MC (2015) Neoplasia 17(12): 862-70
    › Primary publication · 26696368 (PubMed) · PMC4688562 (PubMed Central)