Welcome to the Ihrie Lab @ Vanderbilt!  We are interested in the fundamental development of the neural stem cell niche and the etiology and treatment of brain tumors.  Click the links above for more information.


Featured publications

  1. Ube3a imprinting impairs circadian robustness in Angelman syndrome models. Shi SQ, Bichell TJ, Ihrie RA, Johnson CH (2015) Curr Biol 25(5): 537-45
    › Primary publication · 25660546 (PubMed) · PMC4348236 (PubMed Central)
  2. Controlling COR competence: BCL-6 regulates neurogenesis and tumor suppression. Chiang C, Ihrie RA (2014) Cancer Cell 26(6): 773-774
    › Primary publication · 25490438 (PubMed)
  3. Sonic hedgehog signaling in the postnatal brain. Álvarez-Buylla A, Ihrie RA (2014) Semin Cell Dev Biol : 105-11
    › Primary publication · 24862855 (PubMed) · PMC4130786 (PubMed Central)
  4. Molecular Characteristics in MRI-Classified Group 1 Glioblastoma Multiforme. Haskins WE, Zablotsky BL, Foret MR, Ihrie RA, Alvarez-Buylla A, Eisenman RN, Berger MS, Lin CH (2013) Front Oncol : 182
    › Primary publication · 23875172 (PubMed) · PMC3708153 (PubMed Central)
  5. Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy. Huillard E, Hashizume R, Phillips JJ, Griveau A, Ihrie RA, Aoki Y, Nicolaides T, Perry A, Waldman T, McMahon M, Weiss WA, Petritsch C, James CD, Rowitch DH (2012) Proc Natl Acad Sci U S A 109(22): 8710-5
    › Primary publication · 22586120 (PubMed) · PMC3365162 (PubMed Central)
  6. Corridors of migrating neurons in the human brain and their decline during infancy. Sanai N, Nguyen T, Ihrie RA, Mirzadeh Z, Tsai HH, Wong M, Gupta N, Berger MS, Huang E, Garcia-Verdugo JM, Rowitch DH, Alvarez-Buylla A (2011) Nature 478(7369): 382-6
    › Primary publication · 21964341 (PubMed) · PMC3197903 (PubMed Central)
  7. Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity. Ihrie RA, Shah JK, Harwell CC, Levine JH, Guinto CD, Lezameta M, Kriegstein AR, Alvarez-Buylla A (2011) Neuron 71(2): 250-62
    › Primary publication · 21791285 (PubMed) · PMC3346180 (PubMed Central)
  8. Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain. Ihrie RA, Alvarez-Buylla A (2011) Neuron 70(4): 674-86
    › Primary publication · 21609824 (PubMed) · PMC3346178 (PubMed Central)
  9. PERP regulates enamel formation via effects on cell-cell adhesion and gene expression. Jheon AH, Mostowfi P, Snead ML, Ihrie RA, Sone E, Pramparo T, Attardi LD, Klein OD (2011) J Cell Sci 124(Pt 5): 745-54
    › Primary publication · 21285247 (PubMed) · PMC3039019 (PubMed Central)
  10. Loss of the desmosomal component perp impairs wound healing in vivo. Beaudry VG, Ihrie RA, Jacobs SB, Nguyen B, Pathak N, Park E, Attardi LD (2010) Dermatol Res Pract : 759731
    › Primary publication · 20628490 (PubMed) · PMC2902749 (PubMed Central)

Community Leaders

Contact Information

2220 Pierce Ave.
761 PRB
Nashville, TN 37232
615-875-0966 (p)

Asa Brockman
6158750966 (p)
6159362911 (f)

Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

Aged, 80 and over Age Factors Aging Blotting, Southern brain tumors cancer Cell Division Cell Line, Tumor Cell Proliferation Choline O-Acetyltransferase Cytarabine developmental biology Genomic Imprinting Glioma growth factors Hedgehog Proteins Luminescent Proteins Mice, Inbred C57BL Microarray Analysis Middle Aged mouse Myocardium neural stem cells neuroscience Skin Smoothened Receptor Sonic hedgehog stem cells Tumor Suppressor Proteins Ubiquitin-Protein Ligases