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We focus on the regulation and role of calcium/calmodulin-dependent protein kinase II (CaMKII) in normal tissues and in neurological or psychiatric disorders. Our lab uses biochemical, molecular and genetic approaches to elucidate basic signaling mechanisms in vitro, and to manipulate them in cultured mammalian cells and in vivo. Cell imaging, electrophysiological and behavioral assays are then used to assess the impact of the manipulations on CaMKII function in normal tissue and in disease models.
- Roger Colbran
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Released March 26, 2019