The primary area of research interest in the Beauchamp laboratory is in colorectal carcinogenesis, the biology of cancer cell invasion and metastasis, and in the identification of novel molecular biomarkers and therapeutic targets in colorectal and other alimentary tract malignancies.  Our work applies DNA microarray and proteomic technology to identify novel biomarkers and therapeutic targets in human colorectal cancer samples.  We also use molecular genetics and cell biological approaches to examine mechanistic questions in cancer biology in both cell culture and mouse models.

Publications

Featured publications

  1. Evaluation of frozen tissue-derived prognostic gene expression signatures in FFPE colorectal cancer samples. Zhu J, Deane NG, Lewis KB, Padmanabhan C, Washington MK, Ciombor KK, Timmers C, Goldberg RM, Beauchamp RD, Chen X (2016) Sci Rep : 33273
    › Primary publication · 27623752 (PubMed) · PMC5021945 (PubMed Central)
  2. Comparison of Nanostring nCounter® Data on FFPE Colon Cancer Samples and Affymetrix Microarray Data on Matched Frozen Tissues. Chen X, Deane NG, Lewis KB, Li J, Zhu J, Washington MK, Beauchamp RD (2016) PLoS One 11(5): e0153784
    › Primary publication · 27176004 (PubMed) · PMC4866771 (PubMed Central)
  3. Four jointed box 1 promotes angiogenesis and is associated with poor patient survival in colorectal carcinoma. Al-Greene NT, Means AL, Lu P, Jiang A, Schmidt CR, Chakravarthy AB, Merchant NB, Washington MK, Zhang B, Shyr Y, Deane NG, Beauchamp RD (2013) PLoS One 8(7): e69660
    › Primary publication · 23922772 (PubMed) · PMC3726759 (PubMed Central)
  4. A network-based gene expression signature informs prognosis and treatment for colorectal cancer patients. Shi M, Beauchamp RD, Zhang B (2012) PLoS One 7(7): e41292
    › Primary publication · 22844451 (PubMed) · PMC3402487 (PubMed Central)
  5. Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of β-catenin. Freeman TJ, Smith JJ, Chen X, Washington MK, Roland JT, Means AL, Eschrich SA, Yeatman TJ, Deane NG, Beauchamp RD (2012) Gastroenterology 142(3): 562-571.e2
    › Primary publication · 22115830 (PubMed) · PMC3343368 (PubMed Central)
  6. Identification and optimization of small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells. Stoops SL, Pearson AS, Weaver C, Waterson AG, Days E, Farmer C, Brady S, Weaver CD, Beauchamp RD, Lindsley CW (2011) ACS Chem Biol 6(5): 452-65
    › Primary publication · 21241068 (PubMed) · PMC3401128 (PubMed Central)
  7. Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer. Smith JJ, Deane NG, Wu F, Merchant NB, Zhang B, Jiang A, Lu P, Johnson JC, Schmidt C, Bailey CE, Eschrich S, Kis C, Levy S, Washington MK, Heslin MJ, Coffey RJ, Yeatman TJ, Shyr Y, Beauchamp RD (2010) Gastroenterology 138(3): 958-68
    › Primary publication · 19914252 (PubMed) · PMC3388775 (PubMed Central)
  8. Oncogenic Ras and transforming growth factor-beta synergistically regulate AU-rich element-containing mRNAs during epithelial to mesenchymal transition. Kanies CL, Smith JJ, Kis C, Schmidt C, Levy S, Khabar KS, Morrow J, Deane N, Dixon DA, Beauchamp RD (2008) Mol Cancer Res 6(7): 1124-36
    › Primary publication · 18644977 (PubMed) · PMC2572152 (PubMed Central)
  9. Variability of in situ proteomic profiling and implications for study design in colorectal tumors. Li JQ, Xu BJ, Shakhtour B, Deane N, Merchant N, Heslin MJ, Washington K, Coffey RJ, Beauchamp RD, Shyr Y, Billheimer D (2007) Int J Oncol 31(1): 103-11
    › Primary publication · 17549410 (PubMed)
  10. Urine PGE-M: A metabolite of prostaglandin E2 as a potential biomarker of advanced colorectal neoplasia. Johnson JC, Schmidt CR, Shrubsole MJ, Billheimer DD, Joshi PR, Morrow JD, Heslin MJ, Washington MK, Ness RM, Zheng W, Schwartz DA, Coffey RJ, Beauchamp RD, Merchant NB (2006) Clin Gastroenterol Hepatol 4(11): 1358-65
    › Primary publication · 16996805 (PubMed)

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Contact Information

1161 21st Ave. South
D2300 Medical Center North
Nashville, TN 37212-2730
USA
615-343-8401 (p)

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Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

Anoikis Carcinoma Cell Line, Tumor Cell Membrane Ceramides colon cancer Gamma Rays gene expression profiling HCT116 Cells Intestine, Small Lasers Liver Neoplasms metastasis Microarray Analysis Microdissection Mitogen-Activated Protein Kinase Kinases mouse models of cancer Nerve Tissue Proteins Plasminogen Activator Inhibitor 1 RNA Stability smad signaling TGF signaling Transcription, Genetic Tumor Suppressor Proteins Unnecessary Procedures wnt signaling Xenopus