We use a variety of animal models, isotopic techniques and analytical methods that allow us to study metabolism from gene to the whole organism. In many of our studies we use physical exercise, insulin-stimulation or diet to perturb metabolic fuel systems. The research we undertake is not only critical to a basic understanding of fuel metabolism but also has important implications to diabetes and heart disease. Possible research projects include studies of:

a. site-specific (extracellular glucose delivery, glucose transport, glucose phosphorylation) regulation of muscle glucose uptake in normal physiology, in insulin resistant states induced by high fat feeding and in insulin sensitive states induced by physical exercise.

b. roles of insulin and glucagon in regulation of hepatic glucose metabolism during and after exercise.

c. integrated control of glucose and fat metabolism in health and disease.

d. central role of energy sensors (AMP kinase, Sirtuins) in control of intra- and interorgan fuel fluxes.

Publications

Featured publications

  1. Rapid changes in the microvascular circulation of skeletal muscle impair insulin delivery during sepsis. Mignemi NA, McClatchey PM, Kilchrist KV, Williams IM, Millis BA, Syring KE, Duvall CL, Wasserman DH, McGuinness OP (2019) Am J Physiol Endocrinol Metab 316(6): E1012-E1023
    › Primary publication · 30860883 (PubMed) · PMC6620574 (PubMed Central)
  2. Dysregulated transmethylation leading to hepatocellular carcinoma compromises redox homeostasis and glucose formation. Hughey CC, James FD, Wang Z, Goelzer M, Wasserman DH (2019) Mol Metab : 1-13
    › Primary publication · 30850319 (PubMed) · PMC6479583 (PubMed Central)
  3. Energy metabolism couples hepatocyte integrin-linked kinase to liver glucoregulation and postabsorptive responses of mice in an age-dependent manner. Trefts E, Hughey CC, Lantier L, Lark DS, Boyd KL, Pozzi A, Zent R, Wasserman DH (2019) Am J Physiol Endocrinol Metab 316(6): E1118-E1135
    › Primary publication · 30835508 (PubMed) · PMC6732653 (PubMed Central)
  4. SIRT2 knockout exacerbates insulin resistance in high fat-fed mice. Lantier L, Williams AS, Hughey CC, Bracy DP, James FD, Ansari MA, Gius D, Wasserman DH (2018) PLoS One 13(12): e0208634
    › Primary publication · 30533032 (PubMed) · PMC6289500 (PubMed Central)
  5. Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase. Hunter RW, Hughey CC, Lantier L, Sundelin EI, Peggie M, Zeqiraj E, Sicheri F, Jessen N, Wasserman DH, Sakamoto K (2018) Nat Med 24(9): 1395-1406
    › Primary publication · 30150719 (PubMed) · PMC6207338 (PubMed Central)
  6. Acute Nitric Oxide Synthase Inhibition Accelerates Transendothelial Insulin Efflux In Vivo. Williams IM, McClatchey PM, Bracy DP, Valenzuela FA, Wasserman DH (2018) Diabetes 67(10): 1962-1975
    › Primary publication · 30002132 (PubMed) · PMC6152344 (PubMed Central)
  7. Automated quantification of microvascular perfusion. McClatchey PM, Mignemi NA, Xu Z, Williams IM, Reusch JEB, McGuinness OP, Wasserman DH (2018) Microcirculation 25(6): e12482
    › Primary publication · 29908041 (PubMed) · PMC6401325 (PubMed Central)
  8. Glycine -methyltransferase deletion in mice diverts carbon flux from gluconeogenesis to pathways that utilize excess methionine cycle intermediates. Hughey CC, Trefts E, Bracy DP, James FD, Donahue EP, Wasserman DH (2018) J Biol Chem 293(30): 11944-11954
    › Primary publication · 29891549 (PubMed) · PMC6066300 (PubMed Central)
  9. The Vasculature in Prediabetes. Wasserman DH, Wang TJ, Brown NJ (2018) Circ Res 122(8): 1135-1150
    › Primary publication · 29650631 (PubMed) · PMC5901903 (PubMed Central)
  10. Reduced Nonexercise Activity Attenuates Negative Energy Balance in Mice Engaged in Voluntary Exercise. Lark DS, Kwan JR, McClatchey PM, James MN, James FD, Lighton JRB, Lantier L, Wasserman DH (2018) Diabetes 67(5): 831-840
    › Primary publication · 29511026 (PubMed) · PMC5909996 (PubMed Central)

Community Leaders

Contact Information

2215 Garland Ave
823 Light Hall
Nashville, TN 37232
United States
615-343-0580 (p)

Deanna Bracy
615-343-0580 (p)
615-322-7236 (f)
Email

Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

Antioxidants Automation Blood Glucose energy sensors exercise extracellular matrix Fasting Feasibility Studies Female glucose uptake hepatic glucose production high fat diet Hyperinsulinism Inflammation Injections, Intraventricular Insulin-Secreting Cells insulin resistance Kupffer Cells Lipid Metabolism Mice, Transgenic Mitochondria, Muscle mitochondrial metabolism Physical Conditioning, Animal Physical Endurance Pro-Opiomelanocortin Random Allocation Reverse Transcriptase Polymerase Chain Reaction Rhodamines