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We use a variety of animal models, isotopic techniques and analytical methods that allow us to study metabolism from gene to the whole organism. In many of our studies we use physical exercise, insulin-stimulation or diet to perturb metabolic fuel systems. The research we undertake is not only critical to a basic understanding of fuel metabolism but also has important implications to diabetes and heart disease. Possible research projects include studies of:

a. site-specific (extracellular glucose delivery, glucose transport, glucose phosphorylation) regulation of muscle glucose uptake in normal physiology, in insulin resistant states induced by high fat feeding and in insulin sensitive states induced by physical exercise.

b. roles of insulin and glucagon in regulation of hepatic glucose metabolism during and after exercise.

c. integrated control of glucose and fat metabolism in health and disease.

d. central role of energy sensors (AMP kinase, Sirtuins) in control of intra- and interorgan fuel fluxes.


Featured publications

  1. 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) effect on glucose production, but not energy metabolism, is independent of hepatic AMPK in vivo. Hasenour CM, Ridley DE, Hughey CC, James FD, Donahue EP, Shearer J, Viollet B, Foretz M, Wasserman DH (2014) J Biol Chem 289(9): 5950-9
    › Primary publication · 24403081 (PubMed) · PMC3937663 (PubMed Central)
  2. Matrix metalloproteinase 9 opposes diet-induced muscle insulin resistance in mice. Kang L, Mayes WH, James FD, Bracy DP, Wasserman DH (2014) Diabetologia 57(3): 603-13
    › Primary publication · 24305966 (PubMed) · PMC4155606 (PubMed Central)
  3. Relaxin treatment reverses insulin resistance in mice fed a high-fat diet. Bonner JS, Lantier L, Hocking KM, Kang L, Owolabi M, James FD, Bracy DP, Brophy CM, Wasserman DH (2013) Diabetes 62(9): 3251-60
    › Primary publication · 23801576 (PubMed) · PMC3749347 (PubMed Central)
  4. Hyaluronan accumulates with high-fat feeding and contributes to insulin resistance. Kang L, Lantier L, Kennedy A, Bonner JS, Mayes WH, Bracy DP, Bookbinder LH, Hasty AH, Thompson CB, Wasserman DH (2013) Diabetes 62(6): 1888-96
    › Primary publication · 23349492 (PubMed) · PMC3661617 (PubMed Central)
  5. Regulation of endogenous glucose production in glucose transporter 4 over-expressing mice. Berglund ED, Li CY, Ayala JE, McGuinness OP, Wasserman DH (2012) PLoS One 7(12): e52355
    › Primary publication · 23285006 (PubMed) · PMC3524103 (PubMed Central)
  6. AMP-activated protein kinase (AMPK)α2 plays a role in determining the cellular fate of glucose in insulin-resistant mouse skeletal muscle. Lee-Young RS, Bonner JS, Mayes WH, Iwueke I, Barrick BA, Hasenour CM, Kang L, Wasserman DH (2013) Diabetologia 56(3): 608-17
    › Primary publication · 23224579 (PubMed) · PMC4075509 (PubMed Central)
  7. Muscle-specific vascular endothelial growth factor deletion induces muscle capillary rarefaction creating muscle insulin resistance. Bonner JS, Lantier L, Hasenour CM, James FD, Bracy DP, Wasserman DH (2013) Diabetes 62(2): 572-80
    › Primary publication · 23002035 (PubMed) · PMC3554359 (PubMed Central)
  8. Emerging role of AMP-activated protein kinase in endocrine control of metabolism in the liver. Hasenour CM, Berglund ED, Wasserman DH (2013) Mol Cell Endocrinol 366(2): 152-62
    › Primary publication · 22796337 (PubMed) · PMC3538936 (PubMed Central)
  9. Mitochondrial antioxidative capacity regulates muscle glucose uptake in the conscious mouse: effect of exercise and diet. Kang L, Lustig ME, Bonner JS, Lee-Young RS, Mayes WH, James FD, Lin CT, Perry CG, Anderson EJ, Neufer PD, Wasserman DH (2012) J Appl Physiol (1985) 113(8): 1173-83
    › Primary publication · 22653994 (PubMed) · PMC3472490 (PubMed Central)
  10. Hyperinsulinemic-euglycemic clamps in conscious, unrestrained mice. Ayala JE, Bracy DP, Malabanan C, James FD, Ansari T, Fueger PT, McGuinness OP, Wasserman DH (2011) J Vis Exp (57)
    › Primary publication · 22126863 (PubMed) · PMC3308587 (PubMed Central)

Community Leaders

Contact Information

2215 Garland Ave
823 Light Hall
Nashville, TN 37232
United States
615-343-0580 (p)

Deanna Bracy
615-343-0580 (p)
615-322-7236 (f)

Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

Antioxidants Arterial Pressure Blood Glucose Disease Progression energy sensors Exercise exercise extracellular matrix Female glucose uptake hepatic glucose production high fat diet Humans Hyperinsulinism Hypoglycemia Injections, Intraventricular Insulin-Secreting Cells insulin resistance Lipid Metabolism Macrophages, Peritoneal Mice, Transgenic mitochondrial metabolism Mutation Myocardial Ischemia Non-alcoholic Fatty Liver Disease Phosphorylation Pro-Opiomelanocortin Reverse Transcriptase Polymerase Chain Reaction