The Yull lab, within the Cancer Biology department, studies the NF-kappaB family of transcription factors, master regulators of many critical processes such as proliferation, apoptosis, immune responses and inflammation. Given its wide range of functions, it is unsurprising that NF-kappaB plays roles in basic development and in most diseases including cancer. Our laboratory has generated a number of mouse models to investigate these roles in development; breast, lungs, limbs and the immune system. We are also interested in the roles played by NF-kappaB signaling in disease, especially within breast and lung cancer.


Featured publications

  1. Macrophage-specific RNA interference targeting via "click", mannosylated polymeric micelles. Yu SS, Lau CM, Barham WJ, Onishko HM, Nelson CE, Li H, Smith CA, Yull FE, Duvall CL, Giorgio TD (2013) Mol Pharm 10(3): 975-87
    › Primary publication · 23331322 (PubMed) · PMC3595119 (PubMed Central)
  2. Intraductal injection of LPS as a mouse model of mastitis: signaling visualized via an NF-κB reporter transgenic. Barham W, Sherrill T, Connelly L, Blackwell TS, Yull FE (2012) J Vis Exp (67): e4030
    › Primary publication · 22971993 (PubMed) · PMC3490260 (PubMed Central)
  3. Tumor microenvironment complexity: emerging roles in cancer therapy. Swartz MA, Iida N, Roberts EW, Sangaletti S, Wong MH, Yull FE, Coussens LM, DeClerck YA (2012) Cancer Res 72(10): 2473-80
    › Primary publication · 22414581 (PubMed) · PMC3653596 (PubMed Central)
  4. A critical role for macrophages in promotion of urethane-induced lung carcinogenesis. Zaynagetdinov R, Sherrill TP, Polosukhin VV, Han W, Ausborn JA, McLoed AG, McMahon FB, Gleaves LA, Degryse AL, Stathopoulos GT, Yull FE, Blackwell TS (2011) J Immunol 187(11): 5703-11
    › Primary publication · 22048774 (PubMed) · PMC3221921 (PubMed Central)
  5. NF-kappaB activation within macrophages leads to an anti-tumor phenotype in a mammary tumor lung metastasis model. Connelly L, Barham W, Onishko HM, Chen L, Sherrill TP, Zabuawala T, Ostrowski MC, Blackwell TS, Yull FE (2011) Breast Cancer Res 13(4): R83
    › Primary publication · 21884585 (PubMed) · PMC3236346 (PubMed Central)
  6. Inhibition of NF-kappa B activity in mammary epithelium increases tumor latency and decreases tumor burden. Connelly L, Barham W, Onishko HM, Sherrill T, Chodosh LA, Blackwell TS, Yull FE (2011) Oncogene 30(12): 1402-12
    › Primary publication · 21076466 (PubMed) · PMC3063854 (PubMed Central)
  7. Activation of nuclear factor kappa B in mammary epithelium promotes milk loss during mammary development and infection. Connelly L, Barham W, Pigg R, Saint-Jean L, Sherrill T, Cheng DS, Chodosh LA, Blackwell TS, Yull FE (2010) J Cell Physiol 222(1): 73-81
    › Primary publication · 19746431 (PubMed) · PMC2783968 (PubMed Central)
  8. The protein kinase IKKepsilon regulates energy balance in obese mice. Chiang SH, Bazuine M, Lumeng CN, Geletka LM, Mowers J, White NM, Ma JT, Zhou J, Qi N, Westcott D, Delproposto JB, Blackwell TS, Yull FE, Saltiel AR (2009) Cell 138(5): 961-75
    › Primary publication · 19737522 (PubMed) · PMC2756060 (PubMed Central)
  9. Myeloid cells control termination of lung inflammation through the NF-kappaB pathway. Han W, Joo M, Everhart MB, Christman JW, Yull FE, Blackwell TS (2009) Am J Physiol Lung Cell Mol Physiol 296(3): L320-7
    › Primary publication · 19098124 (PubMed) · PMC2660215 (PubMed Central)
  10. The nuclear factor-kappaB pathway controls the progression of prostate cancer to androgen-independent growth. Jin RJ, Lho Y, Connelly L, Wang Y, Yu X, Saint Jean L, Case TC, Ellwood-Yen K, Sawyers CL, Bhowmick NA, Blackwell TS, Yull FE, Matusik RJ (2008) Cancer Res 68(16): 6762-9
    › Primary publication · 18701501 (PubMed) · PMC2840631 (PubMed Central)

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Contact Information

1161 21st Avenue South
B3302 Medical Center North
Nashville, TN 37232
United States of America
615-343-2568 (p)
615-343-2569 (f)

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Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

Antineoplastic Agents breast cancer Chemokines, CXC DNA, Complementary Doxycycline Epithelial Cells Genes, ras Genes, Reporter Gravitation Hydrolysis I-kappa B Proteins inflammation Intestines Intubation, Intratracheal Kinetics macrophages mammary development nanoparticles NF-kappaB ovarian cancer Prostatic Neoplasms Protein Serine-Threonine Kinases Quinoxalines Smoking Synaptotagmin I Toll-Like Receptors Tumor Microenvironment