The Hong laboratory is focused on Chemical Biology of vertebrate development and stem cell differentiation.
1) Chemical Genetics of Embryonic Development: In a manner analogous to classic mutagenesis screens, we conduct high-throughput chemical screens using zebrafish to discover small molecules that specifically perturb embryonic pattern formation. Using the chemical genetic approach, incorporating molecular cell biology, embryology, biochemistry and medicinal chemistry, we have discovered exquisitely selective modulators of the Bone Morphogenetic Protein (BMP), Wnt, Innate Immunity and Hedgehog pathways, as well as important new signaling components that direct early vertebrate development.
2) Regenerative Chemical Biology: Since small molecules that perturb embryonic patterning do so by promoting development of specific cell and tissue types, we predict that they will be valuable chemical reagents for stem cell research and cell-based regenerative therapies. We have developed chemical methods for robust induction of neurogenesis and cardiomyogenesis in pluripotent stem cells, including induced pluripotent cells from patients.
3) Drug Discovery/ Experimental Therapeutics: Since aberrant activities of developmental pathways play major roles in pathogenesis of many adult diseases, we are exploring therapeutic potential of our novel small molecules for a number of human diseases. For example, we have made key contributions to the elucidation of BMP signaling as a promising therapeutic target for anemia of chronic disease, heterotopic ossification syndromes, inflammatory bowel disease, and atherosclerosis.
Vanderbilt University School of Medicine
Division of Cardiovascular Medicine
Nashville, TN 37232
No contact person provided
MeSH terms are retrieved from PubMed records. Learn more.
Key: MeSH Term KeywordBlotting, Southern BMP signaling Bone Morphogenetic Protein Receptors, Type II cardiovascular development Cell Line, Tumor chemical biology chemical genetics developmental biology Drug-Related Side Effects and Adverse Reactions Drug Design Drug Discovery Embryonic development Genetic Complementation Test genetics heart Hedgehog signaling induced pluripotent stem cells Interleukin-6 Intestine, Small kinase Liver Neoplasms Membrane Microdomains Mesothelioma MicroRNAs molecular medicine Myocardium Nerve Tissue Proteins Parkinson Disease pharmacology Rats, Nude regenerative medicine Sarcomeres signal transduction Smoothened Receptor stem cell biology stem cells Stomach Transcription, Genetic wnt signaling zebrafish